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02

Can RNA Chemistry Build a Code?

Computational stress test of whether RNA aptazyme systems can meet the Evolution 2.0 Prize's 5-bit threshold without a pre-designed code. Lays out a four-quantity framework (per-channel noise, orthogonal channels, crosstalk, Hill coefficient), documents which architectures are ruled out and why, flags Blahut–Arimoto capacity estimates as methodology-sensitive, and proposes wet-lab dose-response CV profiling as the single rate-limiting measurement.

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